Intussusception occurs when a proximal portion of the bowel (intussusceptum) telescopes into the direct adjacent distal portion (intussuscepiens) causing edema, irritation, and compression of the mesenteric blood vessels. As a result, the bowel will be obstructed, and the affected intestinal portion may die and bleed. Bleeding and outpouring of mucus are responsible for the production of the characteristic "currant jelly" stool. Sudden onset of intermittent pain and vomiting in a healthy child are the main clinical features of this condition. The most common form of intussusception is the ileocolic (ileum telescoped into the colon) which usually affects infants and young children under the age of one year. Noticeably, males are three times more affected than females. It has been found that some conditions can increase the chance to have intussusception such as; cystic fibrosis, intestinal tumors, and intestinal and upper respiratory tract infections.
The worldwide incidence of intussusception is estimated to be 2:1000 infants. Abdominal X-ray and barium enema (a diagnostic and treatment procedure) are used in the diagnosis of intussusception. Intussusception is a life-threatening condition if not treated that may cause serious damage to the intestine and internal bleeding, and in the worst cases, peritonitis results. Fortunately, most patients recover completely within 24 hours after treated by surgery.
About 90% of the cases with intussusception are idiopathic. However, familial intussusception has been reported numerously.