Chacko et al. (2001) reported the neurological and systemic abnormalities in 22 children with corpus callosum, seen in a hospital over a period of five years (1993-1997). All children with various neurological problems who were found to have corpus callosum agenesis on CT scan of the brain were included in the study. The patients were examined for syndromes association or metabolic defects, and were investigated with complete blood count, liver and renal function tests, karyotyping, electroencephalogram (EEG), electrocardiography, TORCH serology and thyroid function test. In some children, muscle biopsy, electromyography (EMG), and MRI of the brain were done. During the five year period, out of 2164 children who underwent CT scan of the brain for different reasons, 22 (1.02%) had corpus callosum agenesis. There were 14 males and eight females (mean age at presentation: 2-years and 8-months). The common presentations were seizures (36%) and developmental delay (23%). Cortical atrophy was the most common brain anomaly on CT scan. The chromosome analysis done in eight patients was normal. The selected group included two siblings with CCA; Chacko et al. (2001) were not able to screen their other family members and suggested autosomal recessive inheritance. Another patient with Aicardi Syndrome was found to have an X-linked recessive inheritance of ACC. Since the radiological diagnosis of corpus callosum agenesis was mostly coincidental, Chacko et al. (2001) emphasized on the importance of neuro-radiological imaging in the diagnosis of developmental delay.

Koul et al. (2006) analyzed data from the pediatric neurology department at Sultan Qaboos University Hospital for children undergoing evaluation for developmental delay and epilepsy. Corpus callosum agenesis was the most common neuronal migrational disorder, with 22 patients (55%). Corpus callosum agenesis data were from 1993 to 1997. The ages of affected children ranged from 2 days to 10 years, with a mean age of 2 years 8 months. There were 14 boys and 8 girls. The majority, 20 of 22 cases of corpus callosum agenesis, were nonsyndromic. Corpus callosum agenesis was detected in 1% of all computed tomographic (CT) scans of children less than 12 years age. Eight children (four boys and four girls) in this group had epilepsy. These were infantile spasms in four, generalized tonic-clonic seizures in two, and Lennox-Gastaut syndrome in two.

Alorainy (2006) reviewed and analyzed the MRI studies on 808 pediatric patients (aged 3 days to 15 years) over a 3-year period.  A total of 114 congenital cerebral malformations were identified in 86 of these patients via MRI.  Three patients were identified with Joubert Syndrome.  Corpus callosum dysgenesis, diagnosed in 22 patients, was one of the most common malformations.  Among patients with this condition, the entire corpus callousm was absent in 10 patients.  In nine, corpus callousm was partially affected, in one patient there was global hypoplasia of corpus callosum with no signs of agenesis, while in two patients, part of the body of corpus callosum was not developed.