PCNT gene encodes pericentrin, a protein expressed in centrosomes, which is a vital component of the pericentriolar material (PCM). It plays an important role in the formation of microtubule network, thereby, supporting normal progression of the cell cycle. Absence of pericentrin is known to result in disorganized mitotic spindles and missegregation of chromosomes. Mutations in PCNT gene cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) and Seckel syndrome-4.