Sjogren Syndrome is one of the most common autoimmune disorders, characterized by the body's immune system attacking its own exocrine glands, especially the lacrimal and salivary glands. As a result of reduction of tears and saliva, all affected patients display a characteristic form of dry eyes and mouth. Other clinical features of this condition include aqueous tear deficiency, dental cavities, enlarged parotid glands, fatigue due to lack of sleep, difficulty in swallowing, hoarseness, skin rashes, vaginal dryness, and dry cough. Apart from moisture glands, the disorder may also affect the joints, muscles, nerves, thyroid, and/or kidneys, resulting in arthritis, myositis, neuropathy, thyroiditis, and/or nephritis. Most patients are highly sensitive to spicy foods and alcohol, and are also highly susceptible to oral infections, especially with yeast. The syndrome can present itself in isolation (primary Sjogren syndrome), or in association with any of the other rheumatic autoimmune disorders, such as SLE or rheumatoid arthritis (secondary Sjogren syndrome).
The overall prevalence of Sjogren syndrome is estimated at 1 in 5,000 individuals. The condition is mostly seen in women over 40 years of age. In fact, women are 9 times more likely than men to have this disorder.
A battery of tests and examinations may be performed to diagnose the condition. These include the Schirmer test to assess the working of the tear glands, slit lamp examination to see the extent of dryness in the eye, mouth examination for signs of salivary gland swelling or dental cavities, and the most important of all, a lip biopsy to confirm the diagnosis. Patients' blood can also be checked for anti-thyroid antibodies, rheumatoid factors, antinuclear antibodies, and most importantly, anti-SS-A and anti-SS-B antibodies that are known to occur commonly in Sjogren syndrome. As of now, there is no cure for the condition. Treatment is only symptomatic in nature, and includes moisture therapy, use of non-steroidal anti-inflammatory drugs, and other immunosuppressive medications. Prognosis for the condition varies from one individual to another. The most seriously affected patients have to manage life-long fatigue, joint pain, blurred vision, and oral infections.