Alport Syndrome is a disorder of defective collagen, leading to abnormalities in the functioning of the kidneys, ears, and eyes. Hearing loss is seen in 80% of boys with ATS.
Hentati et al. (2008) described the incidence and type of ocular abnormalities in 32 patients with Alport's syndrome. The patients belonged to 10 unrelated families in South Tunisia. Genetic survey found five of these families were affected by the X-linked Alport syndrome.