Greig cephalopolysyndactyly syndrome (GCPS) is a rare genetic disorder which influences the growth of the limbs, face, and head. Characteristics of GCPS syndrome differ in patients from very mild to severe. The syndrome features consist of extra fingers or toes (polydactyly), abnormal wide thumb or big toe (hallux), fused skin between the fingers and toes (cutaneous syndactyly), widely spaced eyes (ocular hypertelorism), abnormal size of head (macrocephaly), wide bridge of the nose, and high prominent forehead. Patients with GCPS may seldom suffer from seizures, developmental delay, and intellectual disability.
GCPS syndrome originates due to a mutation in the GLI3 gene which is responsible for normal shaping of the organs and tissues prior to birth.