Atherosclerosis Susceptibility

Alternative Names

  • ATHS
  • Atherogenic Lipoprotein Phenotype
  • ALP
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WHO-ICD-10 version:2010

Diseases of the circulatory system

Diseases of arteries, arterioles and capillaries

OMIM Number

108725

Mode of Inheritance

Autosomal dominant

Gene Map Locus

19p13.3-p13.2

Description

Atherogenic lipoprotein phenotype (ALP) is a common autosomal dominant trait characterized by decreased HDL-cholesterol, moderately raised triglycerides, increased levels of small, dense LDL, and a two-to four-fold increased risk of myocardial infarction. ALP is treated through employing fenofibrate which is used for increasing the LDL clearance and reducing small and dense LDL elevated levels.

Atherogenic lipoprotein phenotype (ALP) is linked to ATHS gene, which is similar to LDLR gene. The magnitude of risk for ALP was found to robustly depend on the overall plasma concentrations of apolipoprotein (apo) B-containing lipoproteins, which demonstrated the necessity of considering the quality and quantity of LDL subfractions for the estimation of atherosclerosis risk.

Epidemiology in the Arab World

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Other Reports

Bahrain

[See: Kuwait > El-Menyar et al., 2009].

Kuwait

A cross-sectional multicenter study (AGATHA-ME) similar to AGATHA (a Global Atherothrombosis Assessment) was carried out by El-Menyar et al. (2009) to evaluate the degree of atherothrombosis and the employment of ankle-brachial index (ABI) in Middle Eastern countries. The study consisted of a cohort of 1341 patients from five countries including Kuwait, United Arab Emirates, Bahrain, Qatar, and Oman. Subjects were allocated to two groups comprising with-disease and at-risk groups. Atypical ABI (< or = 0.9) was observed in the at-risk subjects comprising 31.5% and in the with-disease subjects comprising 28.2%. The highest frequency of atypical ABI (77.6%) was found in the peripheral arterial disease subjects with a negative predictive value of 97.8. The study verified that the occurrence of atherothrombosis appeared at more than one position and that ABI was found to associate with the risk factor profile, the position, and the degree of atherothrombosis. Furthermore, El-Menyar et al. (2009) demonstrated that gender and diabetes mellitus were found to correlate with the worst parameters.

Oman

[See: Kuwait > El-Menyar et al., 2009].

Qatar

[See: Kuwait > El-Menyar et al., 2009].

United Arab Emirates

[See: Kuwait > El-Menyar et al., 2009].

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