LAMC2 gene encodes for gamma subunit laminin, which binds by disulfide bonds with an alpha and a gamma subunit to form laminin-332 (laminin-5). Laminin-5 is expressed in several fetal tissues, specifically localized to epithelial cells in skin, lung, and kidney. Laminin binds to cells via a high affinity receptor and mediates the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is also important for wound healing.
Mutations in LAMC2 gene are associated with junctional epidermolysis bullosa.