The ERCC8 gene encodes a WD repeat protein with a role in substrate recognition by the CSA complex. This complex functions as an E3 ubiquitin ligase with an important role in the transcription-coupled nucleotide excision repair system. The CSA complex ubiquitinates a DNA-binding protein called ERCC6 and causes its proteosomal degradation in a UV-dependant manner. This process is required for recruiting numerous factors to a transcription-coupled repair complex leading to the recovery of RNA synthesis following transcription-coupled repair events.