[See: Saudi Arabia > Cameron, 1993].

Farag and Schimke (1989) described an Arab brother and sister with the phenotype of EDS VI in association with peripheral polyneuropathy, as confirmed by nerve conduction velocity, electromyographic and muscle biopsy. In addition, the siblings also had aortic regurgitation and a mitral valve prolapse. The two siblings were born to consanguineous Bedouin parents and grandparents. Farag and Schimke (1989) proposed that this clinical combination either represented a new subtype of EDS, or manifested itself due to two independent recessive traits expressing themselves in the inbred kindred.

Cameron (1993) described the corneal abnormalities of 11 Arab patients (five boys and six girls) with clinical findings consistent with EDS Type VI. These patients included five Saudis, three Syrians, two Jordanians, and one Yemeni from nine different families. All 11 patients had blue sclera, limbus-to-limbus corneal thickening, curvature abnormality, easily everted eyelids, and hypermobile joints. In addition, all were born to phenotypically normal first cousin consanguineous parents. Systemic abnormalities associated with the generalized connective tissue disorder in the patients included increased skin laxity, pectus excavatum, scoliosis, congenital hip and recurrent shoulder dislocations, high-frequency hearing loss, high arched palate, and mitral valve prolapse. Seven patients experienced corneal rupture spontaneously or following minimal trauma, whereas five patients had peripheral sclerocornea, and acute hydrops occurred in three.

[See: Saudi Arabia > Cameron, 1993].

[See: Saudi Arabia > Cameron, 1993].