FBXO32 encodes a protein belonging to the F-Box Only (FBXO) family of proteins. This family is characterized by an approximately 50 amino acid long motif, the F box. By linking with other components through the F box, The FBXO32 protein forms the SCF (Skp1, Cullin-1, F-box) E3 ubiquitin ligase complex. The function of the SCF ubiquitin ligase is to mediate the ubiquitination and subsequent proteasomal degradationof target proteins.
Animal studies have helped further elucidate the role of this gene. It was found that in mice, FBXO32 plays a critical role in muscle atrophy. Also, FBXO32 knockout mice have been shown to develop cardiomyopathy due to intracellular protein accumulation and cardiomyocyte apoptosis. These findings suggest a possible role of FBXO32 in the development of cardiomyopathy in humans. However, additional research is needed to confirm this theory.