The Macrophage Migration Inhibitory Factor (MIF) gene encodes a lymphokine involved in numerous cellular process such as cell-mediated immunity, immunoregulation, and inflammation. It regulates the function of macrophages in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine forms a complex with the JAB1 protein, which may play a role in integrin signaling pathways. Recent studies have also pointed out to a role of this gene in processes beyond immune regulation, including cell proliferation and differentiation, and tumorigenesis.
Studies have supported the notion that MIF-directed therapies might offer new treatment opportunities for human diseases in the future.