Hypotrichosis Lymphedema Telangiectasia Syndrome (HLTS) is a rare disorder characterized, as the name suggests, by the triad of sparse hair, childhood onset-lymphedema, and telangiectasia. The telangiectasia is particularly prominent on the palms of the hands. Lymphedemas are manifested by the disturbances in the maintenance of proper vasculature, especially in the lower limbs and eyelids. Defects in hair follicle development lead to progressive scalp hair loss and the absence of eyebrows and eyelashes. Some patients have been known to develop renal functional abnormalities later on in childhood.
Diagnosis is based on the clinical features and upon molecular diagnostics for confirmation. Treatment is symptomatic and varies from patient to patient.