The CPNE6 gene encodes Copine VI, a member of the copine protein family. Copines are evolutionarily conserved calcium-dependent phospholipid-binding proteins. Copine VI contains two N-terminal C2 domains with aspartate residues required for calcium and phospholipid binding as well as a C-terminal von Willebrand factor A domain. While the exact function of this protein is yet to be elucidated, it is predicted to play a role in membrane trafficking and synaptic plasticity. Its location in the cell body and dendrites of neurons suggests a role for copine VI in postsynaptic events.