DNHD1 encodes Dynein Heavy Chain Domain 1, a protein belonging to the Dynein family of cytoskeletal motor proteins. While the protein is yet to be fully characterized, it is believed to carry out motor-driven movement along microtubules coupled to the hydrolysis of ATP. The ability of Dynein proteins to move to the minus end of microtubules, also known as retrograde transport, is essential for the transport of cell cargo, to provide forces and displacements required in mitosis, and to drive the beat of cilia and flagella.