The MPDZ gene encodes a protein with multiple PDZ domains. These PDZ domains are protein motifs known to mediate protein-protein interactions; specifically, they interact with the C-terminal tail sequences of certain ion channel subunits and G protein-coupled receptors. The MPDZ protein is involved in cell adhesion and the viral process. It is believed to interact with HTR2C (a G-protein-coupled receptor for serotonin) and induce its clustering at the cell surface.
The gene has been implicated in Hydrocephalus, Nonsyndromic, Autosomal Recessive 2 (HYC2), a congenital communicating hydrocephalus resulting in macrocephaly, seizures and mildly decreased IQ.