The FBXL22 gene encodes a member of the F-box family of proteins, named for the presence of a characteristic 40-amino acid F-box motif. These F-box proteins interact with SKP1 and CUL1 to form SCF complexes (SKP1-CUL1-F-box protein), which function as ubiquitin ligases. F-box proteins act as the substrate recognition component of these complexes. The SCF complex consisting of FBXL22 specifically targets the sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) for ubiquitination.