The ADGRB2 gene encodes Adhesion G Protein-Coupled Receptor B2, a seven-span transmembrane orphan receptor belonging to the secretin receptor family. This protein, also known as BAI2, is found specifically in the brain and functions as an inhibitor of angiogenesis. It is involved in the G protein-coupled receptor signaling pathway and the cell surface receptor signaling pathway. Based on its function and localization, it is believed to play a role in the positive regulation of synapse assembly and peripheral nervous system development.

The ADGRB2 gene is located on the short arm of chromosome 1. It spans a length of 37.7 kb of DNA and its coding sequence is spread across 32 exons. The gene encodes a 172.6 kDa protein product consisting of 1585 amino acids. Four isoforms of the ADGRB2 protein exist due to alternatively spliced transcript variants. ADGRB2 is found to be specifically expressed in the brain and cerebrospinal fluid.