The ASB3 gene encodes a protein belonging to the ankyrin repeat and SOCS box-containing (ASB) family. The ASB3 protein forms the substrate-recognition component of an E3 ubiquitin ligase complex. This complex carries out the ubiquitination of target proteins, which is a post-translational modification that demarcates them for subsequent proteasomal degradation. ASB3 is also believed to play a role in intracellular signal transduction.