The CABP1 gene encodes Calcium Binding Protein 1, a neuron-specific member of the calmodulin superfamily that is responsible for modulating the calcium ion-dependent activity of inositol trisphosphate receptors as well as P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. It is involved in the negative regulation of protein import into the nucleus and in preventing NMDA receptor-induced cellular degeneration. By carrying out its function, CABP1 is also believed to play a role in neuronal signal transduction and memory.

The CABP1 gene is located on the long arm of chromosome 12. It spans a length of 26.7 kb of DNA and its coding sequence is contained within 9 exons. The gene encodes a 39.8 kDa protein product consisting of 370 amino acids, known as the caldendrin isoform. Other isoforms of the CABP1 protein include the 25 kDa L-CaBP1, the 19 kDa S-CaBP1, and the 8 kDa Calbrain. Predominant expression of the gene is seen in the retina and the brain.