The CLSTN2 gene encodes Calsyntenin 2, an integral membrane protein that consists of an N-terminal signal sequence, 2 cadherin repeats, a C-terminal transmembrane domain and a cytoplasmic C-terminus. While the exact function of calsyntenin 2 is yet to be fully characterized, it is known to be a calcium-ion binding protein that plays a role in synaptic transmission and synapse assembly. It is also suggested to be involved in homophilic cell adhesion via plasma membrane adhesion molecules.