BK channels are a type of large-conductance potassium channel that can be activated by both intracellular calcium ions and membrane depolarization. The channel consists of 4 alpha subunits encoded by the KCNMA1 gene as well as tissue-specific optional auxiliary subunits encoded by different genes. The LRRC52 gene is responsible for encoding one such auxillary gamma subunit of the BK channel. The LRRC52 subunit is found to regulate channel gating properties such as adjusting potassium-ion current kinetics and apparent calcium sensitivity as well as altering the channel’s voltage dependence of activation toward more negative voltages.