The NECAP2 gene encodes a protein belonging to the adaptin-ear-binding coat-associated protein family. As the protein has not yet been fully characterized, current knowledge of its function is mainly inferred from studies on its orthologs. Research on rat brain clathrin-coated vesicles helped identify a role for Necap2 in clathrin-mediated endocytosis and vesicle-mediated protein transport. The protein was found to contain a WVQF motif that helped mediate its interaction with AP2A1, a subunit of the AP-2 complex.