The protein encoded by SLC30A8 gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. SLC30A8 is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist, which confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). [From RefSeq]
