Mégarbané (2003) described two male cousins, both born to consangunieous parents, who presented with mental reatardation and facial dysmorphism. Both patients were described as having severe mental retardation, short stature, optic atrophy, abnormal EEG, and similar facial anomalies including microcephaly, hypertelorism, thin upper lip, ptosis, and absent ear lobes. The authors described this as novel MCA/MR syndrome.