Oral-facial-digital (OFD) type 2 is characterized by hand and feet deformities, facial deformities, midline cleft of the upper lip and tongue hamartomas. [From Orphanet]
Ghossaini et al (2002) described a male Lebanese patient with several congenital anomalies, including polysyndactyly, hypertelorism, partial median cleft of the upper lip, and 2 solitary tongue masses. Parents were consanguineous, and a similarly affected sister died as a neonate. The authors concluded that the patient presneted with a variant form of oFD Type II, with tongue lipomas instead of hamartomas.