Matrix Metallopeptidase 3

Alternative Names

  • Stromelysin 1
  • STMY1
  • STR1
  • SL1
  • Transin

Associated Diseases

Lung Cancer
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OMIM Number

185250

NCBI Gene ID

4314

Uniprot ID

P08254

Length

7,815 bases

No. of Exons

10

No. of isoforms

1

Protein Name

Stromelysin-1

Molecular Mass

53977 Da

Amino Acid Count

477

Genomic Location

chr11:102,835,797-102,843,611

Gene Map Locus
11q22.2

Description

MMP3 gene encodes a zinc-dependent endopeptidase named Stromelysin-1, which belongs to the matrix metalloproteinase (MMP) family of proteins. Stromelysin-1 is involved in the breakdown of  fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. It plays a critical role in wound repair, progression of atherosclerosis, and tumor initiation.

Mutations in MMP3 are associated with coronary heart disease 6, arthritis, and different types of cancers, including colorectal, breast, ovarian, lung, bladder, liver, and renal cancer.

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NG_012100.1:g.3391_3395=LebanonNC_000011.10:g.102845217_102845221=AssociationLung CancerNG_012100.1:g.3391_3395=35068180
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