Myosin, Heave Chain 14, Nonmuscle

Alternative Names

  • MYH14
  • Nonmuscle Myosin Heavy Chain IIC
  • NMHC IIC
  • KIAA2034
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OMIM Number

608568

NCBI Gene ID

79784

Uniprot ID

Q7Z406

Length

122,359 bases

No. of Exons

46

No. of isoforms

6

Protein Name

Myosin-14

Molecular Mass

227871 Da

Amino Acid Count

1995

Genomic Location

chr19:50,188,186-50,310,544

Gene Map Locus
19q13.33

Description

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_024729.3:c.1126G>TLebanon; Saudi Arabia;...NC_000019.10:g.50244277G>TBenign, Likely Benign, Uncertain SignificanceLikely BenignDeafness, Autosomal Recessive 3NG_011645.1:g.45650G>T; NM_024729.3:c.1126G>T; NP_079005.3:p.Gly376Cys1191032802199
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