Mutated in Colorectal Cancers

Alternative Names

  • MCC
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OMIM Number

159350

NCBI Gene ID

4163

Uniprot ID

P23508

Length

466,725 bases

No. of Exons

26

No. of isoforms

2

Protein Name

Colorectal mutant cancer protein

Molecular Mass

93027 Da

Amino Acid Count

829

Genomic Location

chr5:113,022,099-113,488,823

Gene Map Locus
5q22.2

Description

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001085377.2:c.152G>T Lebanonchr5:113488263Uncertain SignificanceBreast CancerNG_012265.1:g.5568G>T; NM_001085377.2:c.152G>T ; NP_001078846.2:p.Gly51Val
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