SLC26A3 (or DRA) is the major apical anion Na-independent exchanger mediating Cl(-) absorption in intestinal epithelial cells. SLC26A3 is primarily expressed in the apical brush border membrane of ileal enterocytes and colonic epithelium. Disturbances in SLC26A3 function and expression have been implicated in diarrheal conditions such as congenital secretory chloride diarrhea (DIAR1) and inflammatory bowel diseases.