In 2003, the Hamad Medical Corporation, in partnership with the University Children's Hospital of Heidelberg built a comprehensive newborn screening program. Between December 2003 and July 2006, Lindner et al. (2007) investigated 25,214 neonates born in Qatar for inborn errors of metabolism and endocrine disorders. One neonate was diagnosed with MCC deficiency. Result of newborn screening was available at 10-days of age, while treatment was started at 42-days.

Al-Odaib et al. (2006) described the long-term follow-up of a Saudi patient with Biotin-Resistant MCC Deficiency. The female patient, born to consanguineous parents, presented at 2-months of age with tachypnea, gastro-esophageal reflux, diarrhea and acidosis. Tandem MS identified MCC Deficiency, and she was plaved on MSUD formula with isoleucine and valine. She was normal up to 17-months, when she developed a severe respiratory tract infection, and was found to have thrombocytopenia, which resolved spontaneously after a month. She remained a healthy child with appropriate age neuro-developmental milestones until the time of the report, during which time she was 6.5-years old. Tanden MS analysis of both parents and sibs revealed normal parameters. Enzyme analysis in the patient's fibroblasts revealed an isolated MCC deficiency.

Moammar et al. (2010) reviewed all patients diagnosed with inborn errors of metabolism (IEM) from 1983 to 2008 at Saudi Aramco medical facilities in the Eastern province of Saudi Arabia. During the study period, 165530 Saudi infants were born, of whom a total of 248 newborns were diagnosed with 55 IEM. Affected patients were evaluated based on clinical manifestations or family history of similar illness and/or unexplained neonatal deaths. Almost all patients were born to consanguineous parents. The number of cases with organic acidopathies was 48 out of 248 (19%). Among them, three cases with 3-methylcrotonylglycinuria were identified. These cases were diagnosed by skin biopsy. The estimated incidence of this condition is 2 in 100,000 live births. The authors concluded that data obtained from this study underestimate the true figures of various IEM in the region. Therefore, there is an urgent need for centralized newborn screening program that utilizes tandem mass spectrometry, and offers genetic counseling for these families.

Elpeleg et al. (1992) found hypotonia as the initial symptom in four sibs, aged 2.5 to 9 years, with isolated 3-MCC deficiency in a non-consanguineous Tunisian-Jewish family. Plasma carnitine was markedly deficient and urinary organic acid analysis demonstrated increased excretion of 3-hydroxyisolvaleric acid and 3-methylcrotonylglycine. 3-MCC enzyme activity was reduced in skin fibroblasts.