Autosomal Recessive Spinocerebellar Ataxia 2 (SCAR2) is a neurological disorder characterised by congenital nonprogressive ataxia, delay in language acquisition, persistent dysarthria, strabismus, nystagmus, hypotonia, and mental retardation.
Megarbane et al. (1999) studied 12 individuals, aged 25 to 46 years from a large consanguineous Christian Maronite family with cerebellar ataxia and short stature. The patients showed abnormalities in psychomotor development, delayed speech acquisition from infancy and mild to severe forms of ataxic gait at 18-20 years of age. At the time of examination, moderate to severe dysarthria was also observed in the patients.
Delague et al. (2001) performed genome-wide scan in the same family described by Megarbane et al. (1999). The genetic locus in each of the studied individuals was narrowed down to a 12.1cM region on 9q34-qter between D9S67 and D9S312.