Gerodermia osteodysplastica (GO) is a rare autosomal recessive disorder characterized by premature aging signs such as osteoporosis, joint laxity, wrinkled and lax skin with reduced elasticity. Osteoporosis in affected patients is associated with vertebrae compression and susceptibility to fractures. Growth deficiency and intellectual disability are also noted in patients with GO.
Gerodermia osteodysplastica results from mutations in GORAB gene.