Hydatidiform Mole, Recurrent, 1

Alternative Names

  • HYDM1
  • Hydatidiform Mole
  • HYDM
  • Hydatidiform Mole, Complete
  • CHM
  • Gestational Trophoblastic Disease
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WHO-ICD-10 version:2010

Pregnancy, childbirth and the puerperium

OMIM Number

231090

Mode of Inheritance

Autosomal recessive

Gene Map Locus

19q13.42

Description

A hydatidiform mole is an abnormal pregnancy characterized by hydropic placental villi, trophoblastic hyperplasia, and poor fetal development. Familial recurrent hydatidiform mole is an autosomal recessive condition in which women experience recurrent pregnancy losses, predominantly complete hydatidiform mole (CHM). However, unlike sporadic CHMs, which are androgenetic with 2 paternal chromosome complements, CHMs associated with familial recurrence are genetically biparental in origin with both a maternal and a paternal contribution to the genome. Other pregnancy losses in this condition include partial hydatidiform mole, stillbirths, ectopic pregnancies, early neonatal deaths, and miscarriages, some of which may be undiagnosed molar pregnancies. Normal pregnancies are extremely rare in families with this condition. [From OMIM]

Epidemiology in the Arab World

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Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
231090.1.1LebanonFemaleYesYes Hydatidiform moleNM_139176.3:c.352+1G>AHomozygousAutosomal, RecessiveHelwani et al. 1999; Moglabey et al. 1999; Murdoch et al. 2006
231090.1.2LebanonFemaleYesYes Hydatidiform moleNM_139176.3:c.352+1G>AHomozygousAutosomal, RecessiveHelwani et al. 1999; Moglabey et al. 1999; Murdoch et al. 2006 Sibling of 231090.1....
231090.1.3LebanonFemaleYesYes Hydatidiform moleNM_139176.3:c.352+1G>AHomozygousAutosomal, RecessiveHelwani et al. 1999; Moglabey et al. 1999; Murdoch et al. 2006 Cousin of 231090.1.1
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