Epidermolysis bullosa (EB) is a group of inherited disorders characterised by fragility and blistering of skin. Depending on which layer the blisters form in, EB is classified into three types : epidermolysis bullosa simplex , junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. Junctional epidermolysis bullosa is caused by blister formation within the basement membrane and based on the severity, it is further classified into Herlitz type and non-Herlitz type. The Herlitz type is more severe and is inherited in an autosomal recessive pattern. It is caused by mutations in LAMC2, LAMB3 or LAMA3 genes.
Kuwait - A study conducted to determine the overall incidence of genodermatosis in Kuwait Maternity Hospital between 1985 and 1989, Bastaki et al. (1992) reported the incidence of epidermolysis bullosa to be 0.04 per 1000 livebirths.