Patients with Al-Gazali syndrome are characterized by anterior segment anomalies of the eye, clefting, skeletal abnormalities, and early lethality. In addition, patients may exhibit joint contractures.
Al-Gazali et al. (1999) described two sibs, from a highly inbred Palestinian family, with joint contractures, skeletal abnormalities, anterior segment anomalies of the eye, and early lethality. They indicated that the inheritance pattern in the family is suggestive of an autosomal syndrome.
Al-Gazali et al. (1994) reported two sibs, born to consanguineous Sudanese parents, with multiple congenital abnormalities including prenatal and postnatal growth retardation, anterior segment defects of the eye, arachnodactyly with other skeletal abnormalities, congenital heart disease, and early lethality. Al Gazali et al. (1994) concluded that the constellation of anomalies may represent a previously undescribed syndrome with some similarities to Michels syndrome from which it should be differentiated.
[See also: Palestine > Al Gazali et al., 1994; Sudan > Al-Gazali et al., 1999].