Nonbullous congenital ichthyosiform erythroderma is an inflammatory form of ichthyosis characterized by prominent erythroderma and fine white, superficial, semiadherent scales. At birth, 90% of affected individuals present as collodion babies. Palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume are also present.
Al-Zayir and Al-Amro, 2006, conducted a study between January 1990 and December 1995 in King Fahad hospital to document the clinical and epidemiological features of patients with primary hereditary ichthyosis (PHI). Out of 10455 dermatology patients, a total of 71 individuals (44 males and 27 females) were diagnosed with PHI. Nonbullous Ichthyosiform Erythroderma was diagnosed in 29.6% of these cases.