Gordon syndrome is a type of distal arthrogryposis that is characterised by camptodactyly, clubfoot, and cleft palate (rarely in about 25% of subjects). It has an early age of onset and follows an autosomal dominant inheritance pattern.
Heterozygous mutation in the PIEZO2 (Piezo Type Mechanosensitive Ion Channel Component 2) gene is known to cause Gordon syndrome. Mutations in the same gene is also associated with distal arthrogryposis type 5 and Marden-Walker syndrome that has features overlapping those of Gordon syndrome.