Single Immunoglobulin Domain-Containing IL1R-Related Protein

Alternative Names

SIGIRR
TOLL/IL1R 8
TIR8

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Length

11,739 bases

No. of Exons

No. of isoforms

Protein Name

Single Ig IL-1-related receptor

Molecular Mass

45679 Da

Amino Acid Count

410

Genomic Location

chr11:405,715-417,453

Gene Map Locus

11p15.5

Description

Toll-like receptor (TLR) and interleukin-1 receptor (IL1R) family members mediate inflammatory signals that activate nuclear factor kappa-B (NFKB) or mitogen-activated protein kinase (MAPK) pathways. [From OMIM]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_001288706.1:c.-83-12074C>T	Lebanon	NC_000002.12:g.102141867C>T		Benign		NM_001288706.1:c.-83-12074C>T; NP_001275635.1:p.?	2234650

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=sigirr

Contributors

Sami Bizzari: 29.03.2021

Edit History

Sami Bizzari: 29.03.2021