MEIS Homeobox 2

Alternative Names

  • MEIS2
  • MEIS1, Mouse, Homolog of, 2
  • MEIS1-Related Gene 1
  • MRG1
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OMIM Number

601740

NCBI Gene ID

4212

Uniprot ID

O14770

Length

212,108 bases

No. of Exons

16

No. of isoforms

8

Protein Name

Homeobox protein Meis2

Molecular Mass

51790 Da

Amino Acid Count

477

Genomic Location

chr15:36,889,203-37,101,310

Gene Map Locus
15q14

Description

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_170675.5:c.998_1000delUnited Arab EmiratesNC_000015.10:g.36896665TCT[2]Likely Pathogenic, PathogenicLikely PathogenicCleft Palate, Cardiac Defects, and Mental RetardationNG_029108.1:g.209628GAA[2]; NM_170675.5:c.998_1000del; NP_001207411.1:p.Arg333del879255264224962
NM_170677.4:c.1010_1012delUnited Arab EmiratesNC_000015.10:g.36896652_36896654delLikely PathogenicCleft Palate, Cardiac Defects, and Mental RetardationNM_170677.4:c.1010_1012del; NP_733777.1:p.Pro337_Met338delinsLeu
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