Muscle Ras Viral Oncogene Homolog

Alternative Names

  • MRAS
  • Related Ras Viral Oncogene Homolog 3
  • RRAS3
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OMIM Number

608435

NCBI Gene ID

22808

Uniprot ID

O14807

Length

57,888 bases

No. of Exons

10

No. of isoforms

2

Protein Name

Ras-related protein M-Ras

Molecular Mass

23846 Da

Amino Acid Count

208

Genomic Location

chr3:138,347,647-138,405,534

Gene Map Locus
3q22.3

Description

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001085049.2:c.*1011C>TUnited Arab EmiratesNC_000003.12:g.138403280C>TBenignAssociationCoronary Artery Disease, Autosomal Dominant, 1NM_001085049.2:c.*1011C>T; NP_001078518.1:p.?98188701650099
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