Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 1

Alternative Names

  • SLC5A1
  • Sodium-Glucose Transporter 1
  • SGLT1
  • Sodium-Glucose Cotransporter, Intestinal
  • Na+/Glucose Cotransporter, High Affinity
  • NaGT
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OMIM Number

182380

NCBI Gene ID

6523

Uniprot ID

P13866

Length

69,980 bases

No. of Exons

16

No. of isoforms

2

Protein Name

Sodium/glucose cotransporter 1

Molecular Mass

73498 Da

Amino Acid Count

664

Genomic Location

chr22:32,043,049-32,113,028

Gene Map Locus
22q12.3

Description

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_000343.4:c.83A>GLebanonNC_000022.11:g.32043364A>GPathogenicPathogenicGlucose/Galactose MalabsorptionNG_017045.1:g.5333A>G; NM_000343.4:c.83A>G; NP_000334.1:p.Asp28Gly12191266912908
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