Protein Interacting with C Kinase 1

Alternative Names

  • PICK1
  • PICK
  • PRKCA-Binding Protein
  • PRKCABP
  • Protein Kinase C-Alpha-Binding Protein
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OMIM Number

605926

NCBI Gene ID

9463

Uniprot ID

Q9NRD5

Length

18,447 bases

No. of Exons

14

No. of isoforms

2

Protein Name

PRKCA-binding protein

Molecular Mass

46600 Da

Amino Acid Count

415

Genomic Location

chr22:38,057,254-38,075,700

Gene Map Locus
22q13.1

Description

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_012407.4:c.283-176C>TUnited Arab EmiratesNC_000022.11:g.38067528C>TBenignNM_012407.4:c.283-176C>T; NP_036539.1:p.?880669
NM_012407.4:c.283-59=United Arab EmiratesNC_000022.11:g.38067645=BenignNM_012407.4:c.283-59=; NP_036539.1:p.?2076369
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