IFAP syndrome is characterized by ichthyosiform lesions, striking alopecia, short stature, severe photophobia, and mental retardation. Two kinds of dermatological abnormalities have been described in IFAP. The 'classical' IFAP syndrome is characterized by the presence of generalized cutaneous thorn-like projections, giving a 'nutmeg grater' or 'prickly surface of a rose leaf' feeling. However, atypical cases of the syndrome show a generalized lamellar desquamation, with well demarcated psoriasiform lesions involving the buttocks, gluteal fold, or the limbs, associated with inguinal hernia and/or ectrodactyly.