hrombotic thrombocytopenic purpura (TTP) is a blood disorder characterized by the classic pentad of thrombocytopenia, microangiopathic hemolytic anemia, renal failure, neurologic dysfunction, and fever. Microvascular platelet aggregation is the physiological cause of TTP. The platelet aggregation causes formation of thrombi, as well as thrombocytopenia. Symptoms of TTP at first may be general, including fever, malaise, headache and diarrhea. Spontaneous bleeding and bruising (purpura) is also noticed. Thrombocytopenia and hemolysis may occur as early as during early infancy. Later, the affected patient may show symptoms like jaundice, transient paralysis, numbness, convulsions, and/or kidney impairment.
TTP is suspected based on the clinical symptoms. Confirmation of the diagnosis involves studying the blood count, renal function, and markers of hemolysis. Plasma infusion is the most commonly used treatment strategy to control the disease. Along with the plasma infusion, corticosteroids, and hepatitis B vaccination also need to be administered. Sometimes, blood thinning drugs, like aspirin may also be administered.