Cystic Kidney Disease with ventriculomegaly is an extremely rare and lethal congenital disorder. It has an in utero onset and is characterized by the presence of fluid filled sacs in the kidney associated with dilatation of the lateral ventricles of the brain. Hydrocephaly and polydactyly may also be seen.
Indicating clinical significance, mutations in CRB2 gene has been identified in fetuses with cerebral ventriculomegaly with cystic kidney disease.