Nonimmune Hydrops Fetalis is defined as the presence of excess extracellular body fluid in two or more sites, in the absence of any identifiable circulating antibody to RBC antigens. At an incidence rate of between 1:2000 and 1:3000, it is responsible for more than 87% of cases of Hydrops Fetalis. There may be several factors that may lead to the development of Nonimmune Hydrops Fetalis. The three most common of these factors are cardiac failure, anemia, and hypoproteinemia. Approximately a quarter of the cases have no identifiable cause. Fetal infections by Parvovirus, CMV, or Syphilis, and/or lymphatic abnormalities seen in conditions such as Cystic Hygroma, Noonan Syndrome, and others are also likely causes for the development of this condition. Hydrops Fetalis is a common feature of conditions such as Achondrogenesis, Alpha-Thalassemia, Turner Syndrome, and Osteogenesis Imperfecta. Prognosis for the condition is not very good. About 50% of affected fetuses die in utero, and a further 50% of infants born with the condition also succumb to it. Very rarely do affected infants, born before the 30th week of gestation, survive.