Weaver syndrome is an autosomal dominant rare overgrowth syndrome distinguished by accelerated osseous maturation correlated with craniofacial, limb, neurological, skeletal and further abnormalities. Craniofacial symptoms include macrocephaly, broad forehead, hypertelorism, telecanthus, large and low-set ears, long and prominent philtrum, and relative micrognathia. Limb abnormalities consist of prominent finger pads, thin and deeply-set nails, camptodactyly, wide distal long bones, foot deformities, and broad thumbs. Further associated anomalies include psychomotor retardation, hoarse and low-pitched voice, hypertonia, umbilical and inguinal hernia, and excess loose skin. To this point, 30 cases have been reported, most of them being sporadic, however, two families were portrayed as having an autosomal dominant transmission. Prognosis varies with every case as some patients retain a normal life span and with an ordinary adult height. Curative treatments are not available, though every case must be adapted to a multidisciplinary (e.g., neurological, pediatric, orthopedic, genetic counseling, and psychomotor care) management. Though both sexes are affected with Weaver syndrome, the sex ratio was established as 2M:1F.