Salem et al. (2009) investigated the frequencies of the SDF1-3-prime-A, CCR5-Delta32, CCR5-m303, and CCR2-64I mutations in 304 unrelated healthy Bahraini individuals without any known history of HIV-1 infection or AIDS symptoms. The frequency of the SDF1-3-prime-A allele was found to be 26.5%. Salem et al. (2009) concluded that the SDF1-3-prime-A allele is predominant in the Bahraini population and may be associated with resistance to fast HIV-1 infection in Bahrainis, and thus its genotyping can be used for prognosis in HIV-infected individuals.

Voevodin et al. (1999) undertook a molecular study to determine the frequency of the SDF1-3'A mutation in a population sample of native Kuwaitis. The frequency of the SDF1-3'A mutant allele was found to be 0.2593 (95% CI 0.2024-0.3231). Voevodin et al. (1999) concluded that the SDF1-3'A mutation is sufficiently common in Arabs and can be used for prognostic genotyping in HIV-infected individuals from the Gulf countries.

Wakil et al. (2016) studied the association of gene loci with Coronary Artery Disease (CAD) and Myocardial Infarction (MI) in Saudi populations.  A total of 2668 cases and 3000 controls were recruited for the GWAS study and blood was obtained from the arterial access site.  Genotyping and statistical analysis were carried out.  The SNP rs1746049 on the CXCL12 gene was found to have a suggestive association with CAD [p=2.44E-06, OR=0.8(0.73-0.88)].  The allele rs1746049_C was protective against CAD.  While the exact effect of the SNP on the etiology of CAD is currently unknown, it must be noted that previously reported studies have linked CXCL12 to MI, atherosclerosis, carotid intima thickness and type II diabetes mellitus, albeit in different ethnic groups. 

Ben Nasr et al. (2011) explored the influence of CXCL12 polymorphisms in a cohort of Tunisian patients with malignant hematologic diseases multiple myeloma [MM], non-Hodgkin's lymphoma [NHL], Hodgkin's disease, and acute myeloid leukemia [AML], who underwent stem cell mobilization for autologous transplantation versus a group of healthy donors for allogeneic transplantation. Significant associations for the G801A polymorphism were observed exclusively in patients with MM and NHL in contrast to a lack of association in AML patients. Interestingly, Ben Nasr et al. (2011) found an association among healthy allogeneic transplant donors although the analysis was not biased by background disease or chemotherapy (P=.010; odds ratio=2.603; confidence interval [95%]=1.239-5.466).