Lynch et al. (2011) studied a preliminary pedigree of four individuals from a single family with gastric cancer. All four individuals tested positive for a c.1137G>A mutations in the CDH1 gene. A family information service was then conducted where 40 family members gathered and were provided with proper counseling. Twenty-three family members have been tested for CDH1; 13 were positive and 10 were negative. The proband, a CDH1 mutation carrier, has undergone successful prophylactic total gastrectomy.

Al-Moundhri et al. (2010a) sequenced the CDH1 gene among Omanis to investigate the association between CDH1 polymorphisms and gastric cancer (GC) risk. Four CDH1 polymorphisms were analyzed: +54 T>C, -160 C>A, -616 G>C, and -3159 T>C. The -160 -AA genotype was found to be associated with increasing the risk of GC among Omanis, while no association was found between the other polymorphisms and GC risk. Haplotype analysis for the four polymorphisms revealed that the OR of CCGC was 1.5, and that of CAGC was 1.5, but did not reach a statistical significance. Simultaneously, Al-Moundhri et al. (2010b) investigated the association between global and specific DNA methylation levels and clinicopathological features among 105 Omani patients with gastric cancer. Using PCR and pyrosequencing, five CpG methylation sites were measured in the CDH1 gene. An association was found between older age and CDH1 promoter hypermethylation at sites 3, 5 and on average across the five CDH1 sites. In addition, there was an association between male gender and CDH1 promoter hypermethylation at sites 2, 3, 4 and 5.

In a retrospective study of breast cancer patients in the UAE, Altinoz et al (2020) identified four Emirati patients with variants of uncertain significance in the CDH1 gene.